OS


The OS Cell Disrupter is the smallest offering in the Constant Systems Cell Disruption range of products. At approximately 500mm² the OS sits very comfortable on the benchtop but is best suited when used on its tailor made trolley. The OS trolley ensures that the equipment is situated at its optimum working height and is mounted on full swivel and lockable casters that enables safe and free movement of the equipment when needed. The OS is capable of processing volumes from 0.5mL to 8mL per process with a dead loss volume of < 0.1mL per process.

The OS is recommended for total volumes of up to 24mL which is ideal for those users who wish to upgrade from small bench-top techniques such as bead beating and sonication. The OS takes advantage of Constant Systems precise and consistent hydraulic control which is fully scalable through the whole product range from 0.5mL single preparation processing to large volume processing at 150L per hour. This precise control ensures that the entire sample is processed at the operators set pressure to ensure accurate and consistent results and in most cases a single process or pass is adequate therefore multiple passes are not required. The OS model can be utilised for processing fluid, re-suspended, viscous, tissue, plant and frozen sample types.

(click on the image above to enlarge)

Specifications

  • Simple, quick and easy to use
  • No need for compressed air or bottled gas, standard electrical supply required only
  • No need to prime or purge the equipment prior to use. Any air in the system is simply processed at no detrimental effect to the sample or the equipment
  • Design incorporates a stainless steel tray to capture accidental spillages
  • Disruption pressure displayed digitally and is easily and accurately set between 1-40 kpsi
  • Ability to process fluid, re-suspended, viscous, tissue, plant and frozen sample types
  • Collection cups provided can be transferred to and from ice or freezer to aid temperature control of sample
  • Constant Systems precise and consistent hydraulic control ensures that consistency is maintained during each and every process giving you confidence in repeatability with 99% of the sample being processed at the set pressure
  • Fully contained during the process
  • Utilising industry standard media such as Ethanol (70%), Sodium Hydroxide (1 molar) and detergents such as Virkon (1%) the OS models can be easily cleaned using the following methods:
  • Process flow cleaning - simply process cleaning media through the equipment as you would your sample
  • Manual cleaning - All product path components can easily be dismantled for autoclaving or manual cleaning
  • Product path materials are industry standard Stainless Steel 316L and F51 duplex or equivalent, EPDM, GLFPTFE & PEEK 450G ensuring that all sample types and industry standard cleaning media can be processed as standard
  • Unit Dimensions: 475x510x455 mm (DxWxH)
  • Unit Weight: 110 kg
  • Electrical connections - country specific plug type and standard single phase supply via C15 or C20 connection

MC


The MC Cell Disrupter is the most versatile model for small volume processing offered by Constant Systems Limited. At approximately 500mm² the MC sits very comfortable on the benchtop but is best suited when used on its tailor made trolley. The MC trolley ensures that the equipment is situated at its optimum working height and is mounted on full swivel and lockable casters that enables safe and free movement of the equipment when needed. The MC is capable of processing volumes from 0.5mL to 40mL per process and is recommended for volumes up to 80mL which makes the MC ideal for those users who wish to upgrade from small bench-top techniques such as bead beating and sonication. The MC takes advantage of Constant Systems precise and consistent hydraulic control which is fully scaleable through the whole product range from 0.5mL single preparation processing to large volume processing at 150L per hour. This precise control ensures that the entire sample is processed at the operators set pressure to ensure accurate and consistent results and in most cases a single process or pass is adequate therefore multiple passes are not required. The MC model can be utilised in three modes, these being Single Cycle (SC), Multi Cycle (MC) and Re Cycle (RC) for processing fluid, viscous, tissue, plant and frozen sample types.

SC Mode is simply a single cycle process and can be utilised to process 0.5mL - 8mL volumes of all sample types whether fluid, solid, frozen, tissue or plant.

MC Mode can be utilised to process greater than 8mL volumes up to 40mL in each process and recommended for a total volume no greater than 80mL. In MC mode all sample types that are fluid and re-suspended can be processed.

RC Mode enables the user to conduct multiple passes of the same sample (fluid or re-suspended) without collecting and reintroducing the sample time and time again. RC mode is best utilised for very tough sample types such as Gram Positive Bacteria and some Fungi and Algae types. In RC mode a maximum sample volume of up to 80mL can be processed.

(click on the image above to enlarge)

Specifications

  • Simple, quick and easy to use
  • No need for compressed air or bottled gas, standard electrical supply required only
  • No need to prime or purge the equipment prior to use. Any air in the system is simply processed at no detrimental effect to the sample or the equipment
  • Design incorporates a stainless steel tray to capture accidental spillages
  • Disruption pressure displayed digitally and is easily and accurately set between 1-40 kpsi
  • Ability to process fluid, re-suspended, viscous, tissue, plant and frozen sample types
  • Collection cups provided can be transferred to and from ice or freezer to aid temperature control of sample
  • Constant Systems precise and consistent hydraulic control ensures that consistency is maintained during each and every process giving you confidence in repeatability with 99% of the sample being processed at the set pressure
  • Fully contained during the process
  • Utilising industry standard media such as Ethanol (70%), Sodium Hydroxide (1 molar) and detergents such as Virkon (1%) the MC models can be easily cleaned using the following methods:
  • Process flow cleaning - simply process cleaning media through the equipment as you would your sample
  • Manual cleaning - All product path components can easily be dismantled for autoclaving or manual cleaning
  • Product path materials are industry standard Stainless Steel 316L and F51 duplex or equivalent, EPDM, GLFPTFE & PEEK 450G ensuring that all sample types and industry standard cleaning media can be processed as standard
  • Unit Dimensions: 475x510x500 mm (DxWxH)
  • Unit Weight: 110 kg
  • Electrical connections - country specific plug type and standard single phase supply via C15 or C20 connection

CF Range


The CF Cell Disrupter offers Continuous Flow Processing with two models, the CF1 and CF2. Both models offer the same process and differ only by process speed, the CF1 offers up to 6L per hour and the CF2 offers up to 24L per hour processing rates. Both models benefit from a HMI control, a maximum process pressure of 40kpsi (2700 bar), integrated sample cooling jacket, 200mL inlet reservoir (hopper), auto shut down feature for when the process is complete and both models take advantage of Constant Systems precise and consistent hydraulic control which is fully scaleable through the whole product range from 0.5mL single preparation processing to large volume processing at 150L per hour. This precise control ensures that the entire sample is processed at the operators set pressure to ensure accurate and consistent results and in most cases a single process or pass is adequate meaning multiple passes are not required. Both models are capable of processing fluid or re-suspended sample types and are utilised for many sample types such as bacteria, yeast and algae.

CF1 Model

At approximately 700mm² the CF1 is small enough to bench mount if required but is best suited when used on its tailor made trolley. The CF1 trolley ensures that the equipment is situated at its optimum working height and is mounted on full swivel and lockable casters that enables safe and free movement of the equipment when needed. The CF1 is recommended for process volumes in the range of 15mL through to 10L. For those processing larger volumes in this range then the CF1 can be offered with an integrated peristaltic pump fully controlled through the HMI which will ensure that the inlet reservoir is continually fed whilst recirculating the sample to help avoid any settling until the entire sample is processed.

CF2 Model

With a footprint of approx. 700mm² the CF2 is a floor standing model that is recommended for process volumes from 15mL through to 100L. The CF2 is offered with an integrated peristaltic pump as standard. The CF2 is mounted on full swivel and lockable castors that enables safe and free movement of the equipment when needed.

(click on the image above to enlarge)

Specifications

  • Simple, quick and easy to use
  • No need for compressed air or bottled gas, standard electrical supply required only
  • No need to prime or purge the equipment prior to use. Any air in the system is simply processed at no detrimental effect to the sample or the equipment
  • Design incorporates a stainless steel top tray to capture accidental spillages
  • Disruption pressure displayed digitally and is easily and accurately set between 1- 40 kpsi
  • Integrated sample cooling jacket ensures that the sample is kept at optimum temperatures throughout the process
  • Constant Systems precise and consistent hydraulic control ensures that consistency is maintained during each and every process giving you confidence in repeatability with 99% of the sample being processed at the set pressure
  • Utilising industry standard media such as Ethanol (70%), Sodium Hydroxide (1 molar) and detergents such as Virkon (1%) the CF models can be easily cleaned using the following methods
  • Process flow cleaning - simply process cleaning media through the equipment as you would your sample
  • Reverse flow cleaning and full soak - utilising the peristaltic pump your cleaning media can be pumped backwards through the equipment until the inlet reservoir is filled enabling a full soak if required
  • Manual cleaning - All product path components can easily be dismantled for autoclaving or manual cleaning
  • Product path materials are industry standard Stainless Steel 316L and F51 duplex or equivalent, WC, EPDM, GLFPTFE & PEEK 450G ensuring that all sample types and industry standard cleaning media can be processed as standard
  • Automatic shut down once the sample has been fully processed IQ, OQ and PQ available upon request
  • 1PH electrical connections - country specific plug type and standard single phase supply via C15 or C20 connection

CF1

Unit Dimensions: 605x700x740 mm (DxWxH)

Unit Weight: 130 kg

Electrical Supply: 1 Ph electricity as standard,
Americas some areas require 3Ph

CF2

Unit Dimensions: 720x700x1340 mm (DxWxH)

Unit Weight: 240 kg

Electrical Supply: 3 Ph electricity

 

HFR


The HFR is the ideal production model and offers the same lysis efficiency as the standard CSL systems across the full range of processing pressures yet can provide a vastly superior flow rate.

With lysis efficiencies of up to 95% or more and flow rates of up to 150 L/hr, this system can make short work of processing the entire contents of a production scale fermenter or bioreactor, even without prior pelleting and re-suspending.

The intuitive user interface offers complete control of the flow rate while the flow path accumulator ensures that the entire sample is processed smoothly and efficiently. This machine has been shown to give the same lysis results as the CF Range when processing tough to break cells types such as S. cerevisiae and N. oculata and the innovative heat exchange system ensures that the processed sample is completely chilled upon recovery when fitted with a circulating chiller.

(click on the image above to enlarge)

Specifications

  • Incorporates our unique disruption mechanism and precise hydraulic operating control system
  • Disruption pressure easily and accurately set and displayed digitally with a range of up to 40Kpsi as standard
  • Flow rate up to 150 L/hr at maximum pressure
  • Automatic shut down when process is complete
  • Various flow rates are available depending on desired maximum pressure
  • Pressure consistent and stable during the disruption cycle
  • Various configurations available for inlet and outlet, allowing direct connections to upstream and downstream equipment
  • Performance comparable to existing range of Constant Systems Ltd cell disruptors
  • Materials in contact with sample—316L and F51 duplex stainless steel or equivalent, EPDM
  • IQ/OQ available on request
  • Machine Dimensions - 1650 x 900 x 1250 (LxWxH)
  • Machine weight - 875 kg
  • Accumulator Dimension - 650 x 1700
  • Accumulator weight - 210 kg