“For more than two decades, cell disruptors from Constant Systems have been at the heart of our research on membrane transporters. This equipment is safe, reliable, and well-serviced, and it perfectly performs in our applications, again and again”.
Prof. Hendrik W. van Veen
Department of Pharmacology, University of Cambridge,
Fellow of Clare College
The Constant Systems Cell Disruption system provides high integrity membrane components (functional ATP binding cassettes (ABC)) user by Prof Van Veen’s group to study biosensor approach to anti-microbial agent transport across lipid bilayers generated from E.coli
“As the threat of antibiotic resistance increases, there is a particular focus on developing antimicrobials against pathogenic bacteria whose multidrug resistance is especially entrenched and concerning. One such target for novel antimicrobials is the ATP-binding cassette (ABC) transporter MsbA that is present in the plasma membrane of Gram-negative pathogenic bacteria where it is fundamental to the survival of these bacteria.”
